Containers for holding and transporting discarded sharps and re-usable sharps must be:

Containers designated for holding and transporting discarded sharps and re-usable sharps must meet several critical safety standards to ensure effective infection control and minimize the risk of injury.

First, being puncture resistant is essential, as sharp objects such as needles and blades can easily penetrate materials that are not specifically designed to withstand such force. Puncture-resistant containers help prevent accidental needlesticks and other injuries during handling and disposal.

Second, these containers must be leak-proof on the sides and bottom. This characteristic is crucial to prevent any biohazardous materials, which can include blood or infectious substances, from leaking out and contaminating surfaces during transport or storage.

Finally, biohazard labeling is necessary for these containers to clearly identify their contents as hazardous. This labeling serves to inform staff and emergency responders of the potential risks involved when handling these containers, ensuring proper precautions are taken.

In this context, all these features work together to create a safe and compliant system for managing sharps waste, which is why the comprehensive option that includes all essential characteristics is the correct answer.